Some aspects of the organization and evolution of the genetic code
- 1 September 1989
- journal article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 29 (3) , 191-201
- https://doi.org/10.1007/bf02100202
Abstract
In this paper, I define a measure of the relative position of each amino acid in the genetic code by means of a 21-dimensional vector describing its potential for mutation, in a single step, to each of the other amino acids, or to a chain termination codon. This measure allows us to make a systematic investigation of the type and number of the physicochemical properties of the amino acids that were involved in evolution. The polar character and size of amino acids are identified in this analysis as properties that played a leading role in the evolutionary history of the genetic code. The application of cluster analysis and discriminant analysis reveals the characteristics of the structural organization of the genetic code. Finally, I suggest the existence of a relationship between the molecular weight of the amino acids and the number of synonymous codons.Keywords
This publication has 41 references indexed in Scilit:
- The characterization of amino acid sequences in proteins by statistical methodsPublished by Elsevier ,2004
- A multivariate study of the relationship between the genetic code and the physical-chemical properties of amino acidsJournal of Molecular Evolution, 1985
- The apolar surface area of amino acids and its empirical correlation with hydrophobic free energyJournal of Theoretical Biology, 1984
- Evolution of the amino acid code: Inferences from mitochondrial codesJournal of Molecular Evolution, 1983
- Two types of amino acid substitutions in protein evolutionJournal of Molecular Evolution, 1979
- The genetic code as a periodic tableJournal of Molecular Evolution, 1978
- Genetic code correlations: Amino acids and their anticodon nucleotidesJournal of Molecular Evolution, 1978
- A simplified representation of protein conformations for rapid simulation of protein foldingJournal of Molecular Biology, 1976
- Structural invariants in protein foldingNature, 1975
- The origin of the genetic codeJournal of Molecular Biology, 1968