Gene-specific mRNA. II. Regulation of mRNA synthesis in E. coli after infection with bacteriophage T4.
- 1 May 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (5) , 1081-1088
- https://doi.org/10.1073/pnas.55.5.1081
Abstract
In E. coli B cells, infected with bacteriophage T4, transcription of the supposedly early function rII genes was found to occur throughout the latent period. The late function e gene, coding for the protein structure of phage lysozyme, was found to be transcribed immediately after infection, followed by a period of greatly reduced transcription. At later times the rate of transcription is found to increase again. The unusual kinetics of the production of lysozyme messengers have been interpreted as the result of a feedback mechanism for the regulation of mRNA synthesis. Upon entry of the phage genome, all genes are transcribed once, and only those genes whose messengers are translated continue to be transcribed.This publication has 15 references indexed in Scilit:
- Genetic regulatory mechanisms in the synthesis of proteinsPublished by Elsevier ,2010
- The stimulation of RNA synthesis by ribosomes invitroBiochemical and Biophysical Research Communications, 1966
- Gene-Specific Messenger RNA: Isolation by the Deletion MethodScience, 1966
- Size heterogeneity of T2 messenger RNAJournal of Molecular Biology, 1965
- A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membraneJournal of Molecular Biology, 1965
- Control of T2-Specific RNA synthesisJournal of Molecular Biology, 1964
- The Biochemistry of VirusesAnnual Review of Biochemistry, 1963
- EVIDENCE FOR A NONRANDOM READING OF THE GENOMEProceedings of the National Academy of Sciences, 1962
- THE ISOLATION OF T4-SPECIFIC RNA ON A DNA-CELLULOSE COLUMNProceedings of the National Academy of Sciences, 1962
- A study of gene action in ultraviolet-irradiated bacteriophage T4Virology, 1959