Regulation of the c-Abl and Bcr–Abl tyrosine kinases
Top Cited Papers
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 5 (1) , 33-44
- https://doi.org/10.1038/nrm1280
Abstract
The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.Keywords
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