LV.—A STUDY OF THE STIMULATING EFFECT OF SMALL DOSES OF THALLIUM ACETATE ON THE RATE OF THE GROWTH OF HAIR IN THE ALBINO RAT

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Abstract
Within recent years thallium acetate has been rather widely used as a depilatory agent in mycotic diseases of the scalp. Its use in this field has been limited, however, because of the high toxicity of the drug, and also because of the fact that it can be used with safety only for children who have not yet reached the age of puberty. The dose used to produce depilation in human beings is 0.008 Gm. per kilogram of body weight, but in experimental animals the depilatory dose is usually higher. In rats falling of the hair occurs as a result of the administration of doses of from 0.014 to 0.018 Gm. of thallium acetate per kilogram of body weight. Although thallium acetate has heretofore been used almost exclusively for depilatory purposes, it was thought that very small doses might produce the reverse effect, that of stimulating the rate of the growth

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