THE EFFECT OF ESTROGENIC PLAINT EXTRACTS ON THE UTERUS OF THE LABORATORY RAT

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Abstract
The effects of estrogenic substances from various plant sources and of diethylstilbestrol on uterine weight and histology of intact, ovariectomized, hypophysectomized, and hypophysectomized-ovariectomized albino rats have been studied. Unpurified and partially purified extracts of estrogenic plant material as well as chemically known estrogenic compounds brought about marked uterine responses. The absence of the hypophysis and/or the ovary did not appear to interfere with the rate or degree of uterine response. Method of administration of the extracts influenced the physiological effectiveness of a given dose. When incorporated in the diet the effect of the extract is more marked in terms of uterine response than when the same quantity is administered orally by means of a rubber catheter. The probable relationships of the various findings to infertility are discussed.

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