The Mechanism of Phagocytosis from the Adsorption Point of View
- 1 October 1912
- journal article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 12 (3) , 320-360
- https://doi.org/10.1017/s0022172400005040
Abstract
The two processes involved in the phagocytosis of bacilli (B. typhosus) by polymorphonuclear leucocytes in the presence of a sensitising fluid, viz. (1) the sensitisation of the micro-organism, and (2) the phagocytosis of the sensitised micro-organism, have been separately investigated. A single guinea-pig end-piece acted as the sensitising fluid throughout all the experiments.The removal of opsonin by bacillary emulsions was found to run the course of an adsorption process as evidenced by the numerical relations found to subsist between the bound and free opsonin in equilibrium.Also the actual phagocytosis of sensitised or partially sensitised micro-organisms suspended in a neutral fluid (physiological saline) was found, on analysis by similar numerical methods, to proceed as an adsorption process.Keywords
This publication has 3 references indexed in Scilit:
- Über physiologische und Reiz-Bewegungserscheinungen an LeukozytenVirchows Archiv, 1911
- Die verschiedenartigen Nahrungsaufnahmen bei Amöben als Folge verschiedener Colloidalzustände ihrer OberflächenWilhelm Roux' Archiv für Entwicklungsmechanik der Organismen, 1910
- The influence of temperature on phagocytosisProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1908