LEUKOCYTOSIS FOLLOWING THE INTRAMUSCULAR INJECTION OF LIVER EXTRACT

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Abstract
Determinations of the total white cells and the total number and percentage of polymorpho-nuclear neutrophiles in the peripheral circulating blood of 21 normal subjects and 1 patient with influenza were made before and after intramuscular injection of liver extract. A leukocytosis due to both an actual and relative increase in the polymorphonuclear neutrophiles occurred in every instance. The peak of the rise appeared 6 or 7 hrs. after injection and was partially maintained for several hrs. longer. The maximal and minimal individual responses were 185% and 28% above the normal averages of these 2 subjects. The average leukocytic rise in all cases was 80% above normal.

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