Elevated Cerebrospinal Fluid Vaccinia Antibodies in Multiple Sclerosis

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Abstract
Vaccinia virus neutralizing antibodies were measured in the cerebrospinal fluid (CSF) of 187 patients with multiple sclerosis, 87 patients with other neurologic diseases, and 30 normal controls. Detectable antivaccinia antibody was present in the CSF of 30% of the first group, 3% of the second, and none of the third. These findings may have significance in the search for a causal agent in multiple sclerosis.