Short Communication: Comparative activity of 4, 4'-diaminobiphenyl (benzidine) and its terphenyl analogue, 4, 4'-diaminoterphenyl, in two in vitro assays for potential carcinogenicity
- 1 September 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 1 (9) , 801-802
- https://doi.org/10.1093/carcin/1.9.801
Abstract
The carcinogen 4, 4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4, 4'-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structures, indicate that the terphenyl compound is a potential carcinogen. These findings may contribute to an understanding of the mechanism of action of benzidine as a carcinogen.Keywords
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