Aspergillosis and other systemic mycoses. The growing problem

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Abstract
To measure the incidence in the USA of systemic mycoses necessitating hospitalization, discharge records of 1875 hospitals participating in the Professional Activity Study of the Commission on Professional and Hospital Activities were reviewed. Projected incidence rates in 1976 ranged from 23.0/million for histoplasmosis to 0.2/million for blastomycosis. High prevalences of leukemia or lymphoma (5.9-10.2%) or of other malignancies (9.9-13.2%) were recorded in patients with aspergillosis, candidiasis or cryptococcosis. High prevalences of chronic obstructive lung disease (9.6-9.9%) were recorded in those with aspergillosis or histoplasmosis. Marked increases from 1970-1976 were found in the incidence of aspergillosis (158%), actinomycosis (92%), cryptococcosis (78%) and coccidioidomycosis (74%). Increasing numbers of persons with immunosuppressive conditions, migration of susceptible persons into hyperendemic areas and aging of the population contributed to the increases.

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