EFFECT OF PROPYLTHIOURACIL-INDUCED HYPOTHYROIDISM ON SERUM LEVELS OF LUTEINIZING HORMONE AND FOLLICLESTIMULATING HORMONE IN THE RAT
- 1 December 1973
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 59 (3) , 655-656
- https://doi.org/10.1677/joe.0.0590655
Abstract
It has been reported that thyroxine (T4) influences the production and release of gonadotrophins (Contopoulos, Simpson & Koneff, 1958; Contopoulos & Koneff, 1963; Hagino, 1971). No data are available on the circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in hypothyroid rats. The present study was undertaken to investigate the effects of propylthiouracil (PTU)-induced hypothyroidism on serum LH and FSH levels in male and female rats. Eighteen male and 18 female CD rats (Charles River Breeding Lab.) were divided into three equal groups for each sex and maintained in an air-conditioned and lightcontrolled room with 14 h light/day. They had access to Agway Charles River Formula diet and tap water ad libitum. Group I served as the control receiving vehicle only. Group II were fed PTU (Nutritional Biochemicals) by a stomach tube (5 mg/100 g body wt daily) and were injected with T4 (synthetic, Flint Laboratories)Keywords
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