Renal Hyperplasia in the Intact Rat

Publisher Website
Google Scholar
Abstract
Summary Hyperplasia was produced in the kidneys of rats maintained on a hypertensive-inducing regimen of DCA and saline. The hyperplasia in these intact animals was similar to the hyperplasia observed in uninephrectomized rats even to the extent of having a peak mitotic activity on the 2nd day and a lesser one on the 8th day. The long duration of treatment appears to be unnecessary because there was no cumulative effect and the highest peak occurs after only the first injection of DCA. In fact, the long treatment may have an inhibitory effect on the maximum mitotic activity possible with this technique.