Blood keto acid levels during intoxication with inhibitors of carbohydrate metabolism

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Abstract
A study was made of the levels of pyruvate, [alpha]-oxoglutarate and aceto-acetate in the blood of rats poisoned with different inhibitors of carbohydrate metabolism, namely arsenite, maleate iodoacetate, alloxan, malonate and fluoride. Pyruvate levels were also studied in normal and poisoned animals after intraperitoneal injection of a standard dose of sodium pyruvate. Each of the inhibitors caused an increase in the blood level of pyruvate and [alpha]-oxoglutarate, the rise in the latter being particularly great in the maleate-poisoned animals. Alloxan and malonate each caused a large rise in the level of acetoacetate, the other poisons studied causing only a small but significant rise in this acid.