Flexible Drug Molecules and Dynamic Receptors
- 1 November 1977
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 16 (11) , 766-777
- https://doi.org/10.1002/anie.197707661
Abstract
When a small flexible drug molecule binds to its likewise mobile receptor (protein, membrane etc.) the shape and function of both can change. The study of the nature and extent of these changes by several independent methods gives an insight into the mode of action of drugs. The static lock and key model will most probably have to be revised or be replaced by the nebulous concept of dynamic states.Keywords
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