Cytochrome P450 and the arachidonate cascade 1
- 6 January 1992
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 6 (2) , 731-736
- https://doi.org/10.1096/fasebj.6.2.1537463
Abstract
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.Keywords
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