HLA-B27, ankylosing spondylitis, and the spondyloarthropathies

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Abstract
Ankylosing spondylitis is one of a group of conditions thought to have an autoimmune pathogenesis, which also includes several other rheumatic disorders, such as rheumatoid arthritis and juvenile chronic arthritis. They are characterized by disordered immunological responses, causing tissue-specific inflammation and damage, and by their striking immunogenetic associations (Wordsworth 1995). In 1973 the description of a very strong association between HLAB27, one of the immune response genes, and ankylosing spondylitis (Brewerton et al. 1973a; Schlosstein et al. 1973) prompted enormous interest in the immunogenetics of this condition. The odds ratio for HLA-B27 in ankylosing spondylitis is in excess of 100, and is fairly constant across ethnic groups.

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