Proteinuria following Nephroangiography

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Abstract
Following unilateral selective nephroangiography with diatrizoate, changes in urinary concentrations of prealbumin, albumin, IgG and .alpha.2-macroglobulin were analyzed in 8 dogs. All reacted with increased proteinuria. The median increase of urinary albumin concentration was 1300 times (ranges 27-3500). The proteinuria was caused mainly by increased glomerular permeability exhibiting some molecular size selectivity in filtration of the proteins measured. Light microscopy and EM did not reveal any glomerular or tubular abnormalities which could be attributed to effects of the angiography. Apparently, the increased glomerular permeability to proteins might be an effect of disturbance of the electrical hindrance in the glomerular capillary wall.