An Iron Requirement For the Synchronous Progression of Colonic Cells Following Fasting and Refeeding
- 1 September 1978
- journal article
- research article
- Published by Wiley in Cell Proliferation
- Vol. 11 (5) , 513-518
- https://doi.org/10.1111/j.1365-2184.1978.tb00823.x
Abstract
Dietary Fe is a major co-factor in the colonic hyperplasia following fasting and refeeding. The Fe component serves to remove a fasting induced colonic G1 cycle block and produce the resultant synchronous progression of cells through the cycle. Deleting Fe from the refed diet results in no colonic hyperplasia and/or synchronous progression of cells. Colonic steady state cell renewal and its use as a possible tool for the study of in vivo steady state cell renewal is discussed.Keywords
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