CORRELATION OF REGIONAL LYMPH-NODE INVITRO ANTITUMOR IMMUNOREACTIVITY HISTOLOGY WITH COLORECTAL CARCINOMA

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (10) , 3665-3671
Abstract
Lymph nodes from resected specimens of human colorectal carcinoma were investigated for in vitro lymphocyte cytotoxicity against primary cultures of autologous tumor cells. Regional lymph node lymphocytes were cytotoxic in 32 of 142 cases (23%). Altogether 200 nodes were examined and the cytotoxcity correlated directly with sinus histiocytosis, seen in 43 nodes from 35 cases, and with hyperplasia of B [bone marrow-derived] and T [thymus-derived] lymphocyte area combined, seen in 92 nodes from 65 cases. Lymph nodes with combined B and T cell hyperplasia were signficantly more common in cases of good tumor differentiation. The findings suggest that sinus histiocytosis and hyperplasia of both major lymphocyte populations are morphological expressions of in vitro antitumor immunoreactivity in the regional lymph node.

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