The effect of salicylate on the biliary excretion of 14C‐bishydroxycoumarin in rat

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Abstract
1 . The effect of intravenous sodium salicylate on the biliary excretion of 14C-bishydroxycoumarin (14C-BHC) was studied in rats. 2 . Salicylate (88·9 mg/kg) increased the biliary excretion of 14C-radioactivity from a control value of 12·3±2·7% to 29·3±2·5% of the administered dose in 6 h after injection. 3 . During the 6 h period, 11% of the dose of radioactivity underwent biliary recycling in the salicylate-treated rats compared to only 6% in the absence of salicylate. 4 . About 15·3% of the radioactivity excreted in the bile of rats given BHC alone was detected as unchanged BHC, 8·6% was present as BHC-conjugate, conjugates of BHC metabolites accounted for 30·9%, and the remainder consisted of unidentified metabolites. 5 . Salicylate treatment did not significantly alter the excretory pattern of unchanged BHC and its metabolites.