Changes in Pyruvate Kinase Isozymes of Rat Small Intestine during Development and the Synergistic Effect on Them of Thyroid and Glucocorticoid Hormones

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Abstract
Pyruvate kinase [EC 2.7.1.40] isozymes in rat small intestine changed markedly during the postnatal period. The activities of type M2 subunits rapidly increased before weaning, while those of type L subunits decreased slightly. The administration of hydrocortisone induced normal changes prematurely, whereas the administration of thyroxine increased their extent. On simultaneous administration, the 2 hormones had synergistic effects.

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