Natural Killer Cell Response to Lymphocytic Choriomeningitis Virus in Beige Mice

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Abstract
Lymphocytic choriomeningitis virus (LCMV) induced low levels of natural killer (NK) tell activity in C57BL6 mutant beige (bg/bg) mice, which had previously been reported to have no cytotoxic NK cells. NK cell-mediated lysis by bg/bg splenocytes was observed against a cell line (YAC-I) very sensitive to NK cell cytotoxicity, but not appreciably against a less scum live cell line (L-929), The bg/bg mutant mice with this very low NK cell activity and control stains of mice (bg/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role in curtailing viral synthesis before the advent of the specific immune response mechanisms
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