Effect of an Oral Shiga Toxin–Binding Agent on Diarrhea-Associated Hemolytic Uremic Syndrome in ChildrenA Randomized Controlled Trial
Open Access
- 10 September 2003
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 290 (10) , 1337-1344
- https://doi.org/10.1001/jama.290.10.1337
Abstract
Diarrhea-associated hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in previously healthy children in the United States.1 Most cases are caused by an antecedent enteral infection with Shiga toxin–producing strains of Escherichia coli (STEC).1,2 Nearly 40% of patients require temporary dialysis, up to 20% develop serious extrarenal events, and the mortality rate is 3% to 5%.2,3Keywords
This publication has 17 references indexed in Scilit:
- Hemolytic uremic syndrome: epidemiology, pathophysiology, and therapyPediatric Nephrology, 2002
- Pathogenesis of Shiga toxin-induced hemolytic uremic syndromePediatric Nephrology, 2001
- Epidemiology and diagnosis of Shiga toxin-producing Escherichia coli infectionsDiagnostic Microbiology and Infectious Disease, 1999
- Management of patients with hemolytic uremic syndrome demonstrating severe azotemia but not anuriaPediatric Nephrology, 1996
- Hemolytic Uremic SyndromeEmerging Infectious Diseases, 1995
- A Phase I Study of Chemically Synthesized Verotoxin (Shiga-like Toxin) Pk-Trisaccharide Receptors Attached to Chromosorb for Preventing Hemolytic-Uremic SyndromeThe Journal of Infectious Diseases, 1995
- Spectrum of extrarenal involvement in postdiarrheal hemolytic-uremic syndromeThe Journal of Pediatrics, 1994
- Role of Plasminogen-Activator Inhibitor Type 1 in the Pathogenesis and Outcome of the Hemolytic Uremic SyndromeNew England Journal of Medicine, 1992
- Investigation of Shiga-like Toxin Binding to Chemically Synthesized Oligosaccharide SequencesThe Journal of Infectious Diseases, 1991
- Epidemiology of hemolytic-uremic syndrome in Canadian children from 1986 to 1988The Journal of Pediatrics, 1991