Mechanisms of EGF receptor regulation in breast cancer cells
- 1 January 1994
- journal article
- research article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 31 (2-3) , 227-236
- https://doi.org/10.1007/bf00666156
Abstract
Overexpression of the EGF receptor in breast cancer correlates with poor prognosis and failure on endocrine therapy for both ER−/EGFR+ and ER+/EGFR+ tumors, suggesting a role for EGFR in the progression to hormone independence. The identification of specific DNase I hypersensitive site patterns for the EGFR gene in ER+ vs. ER− cells implicates regions of the EGFR first intron in up-regulation of EGFR, while estrogen regulation studies indicate the involvement of a repressor(s) in the maintenance of low levels of EGFR. Based on these findings, a multi-step model is proposed for the progression of breast cancer from a hormone-dependent, ER+/EGFR- phenotype to an aggressive, hormone-independent, ER−/EGFR+ stage.Keywords
This publication has 50 references indexed in Scilit:
- Prevalence of aberrant expression of the epidermal growth factor receptor in human cancersBritish Medical Bulletin, 1991
- Epidermal growth factor receptor (EGFr); results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroupBritish Journal of Cancer, 1991
- Epidermal growth factor receptor in human breast cancer: Correlation with cytosolic and nuclear ER receptors and with biological and histological tumor characteristicsEuropean Journal of Cancer and Clinical Oncology, 1990
- Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNAMolecular Carcinogenesis, 1989
- EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORS ASSOCIATED WITH LACK OF RESPONSE TO ENDOCRINE THERAPY IN RECURRENT BREAST CANCERThe Lancet, 1989
- Epidermal growth factor receptor (EGFr) status associated with failure of primary endocrine therapy in elderly postmenopausal patients with breast cancerBritish Journal of Cancer, 1988
- Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-OncogeneScience, 1987
- Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cellsCell, 1987
- EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCERThe Lancet, 1985
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequencesNature, 1984