Prediction of Lymphatic Metastases by Gleason Histologic Grading in Prostatic Cancer

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Abstract
Patients (90) with prostatic cancer were reviewed retrospectively to assess Gleason grading as a predictor of pelvic nodal metastases and to compare results to previous studies. Positive nodes occurred in 0 and 20% of patients with Gleason sums of 2 to 4 and 5 to 6, respectively, which is consistent with previous data. Nodes were involved in only 44, 60 and 44% of patients with a Gleason sum of 7 to 9, respectively, and nodes were negative in the sole patient with a Gleason sum of 10. The results contrast greatly with previous reports. More experience is required in evaluating the need for staging pelvic lymphadenectomy or treatment in a patient with a given Gleason grade of prostatic cancer.