Insulin Resistance and the Prevention of Diabetes Mellitus

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Abstract
In 1992 the direct costs of diabetes mellitus and its complications in the United States were estimated at a staggering $45 billion,1 more than the total annual cost of the British National Health Service. Preventing this disease and especially its complications would greatly lighten both the human and the economic burdens it imposes. The landmark Diabetes Control and Complications Trial showed convincingly the protective value of blood glucose control in patients with insulin-dependent diabetes,2 and it is likely that the results are applicable to the equally vulnerable and much more numerous group of patients with non-insulin-dependent diabetes mellitus (NIDDM). If . . .