DIETARY-PROTEIN LEVELS AND AFLATOXIN-B1 METABOLISM IN RAINBOW-TROUT (SALMO-GAIRDNERI)

  • 1 January 1978
    • journal article
    • research article
    • Vol. 2  (2) , 379-388
Abstract
Dietary protein effects upon aflatoxin B1-induced liver cancer in rainbow trout were studied by analyzing the activities of several suspected aflatoxin B1 metabolizing enzyme systems. Fish fed diets containing 32%, 52% and 62% fish protein concentrate (FPC) were examined for hepatic cytochrome P-450 content and in vitro cytochrome c reductase, glutathione-S-epoxide transferase (GTr), epoxide hydrase (EH) and aldrin epoxidase (AE) activity. Aflatoxin B1 conversion to aflatoxicol (AFL) was examined. A direct correlation was observed between increased FPC intake and cytochrome P-450 content and AFL production, with increases of 14% and 41%, respectively. With increased FPC intake, decreases in EH (15%), GTr (20%), cytochrome c reductase (13%) and AE (50%) activities were noted. These findings are discussed in relation to AFB feeding trials reported earlier.

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