Early Development of Infants of Birth Weight Less Than 1,000 Grams with Reference to Mechanical Ventilation in Newborn Period

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Abstract
Growth, development and neurologic status were assessed at 1 yr of age in 38 [human] infants of birth wt < 1000 g who were born in 1976-1978. Twenty received mechanical ventilation as newborns, and this group had a significantly higher incidence of respiratory distress syndrome, seizures, cardiac arrest, bronchopulmonary dysplasia and retrolental fibroplasia than those not ventilated. The ventilated infants had a high incidence (70%) of bronchopulmonary dysplasia and of retrolental fibroplasia (20% grade III or IV). Seven of 8 infants with severe developmental delay (>2 SD), 6 of 9 with moderate delay (>1 SD), and 7 of 8 with neurologic disability received ventilation. There was no difference in growth between the ventilated and nonventilated children. Of the total group, 53% showed no problems.

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