Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression

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Abstract
Adolescent depression is a common, chronic, recurrent, and impairing condition that accounts for a substantial proportion of the disability and mortality incurred in this age group.1,2 Untreated depression results in impairment in school, interpersonal relationships, occupational adjustment, and increases the risk for suicidal behavior and completed suicide.3-5 Therefore, the proper treatment of adolescent depression has profound public health implications for youth in this critical stage of development.6-8