Age- and Strain-Related Differences in Metabolic Response to Tyramine in Rats

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Abstract
Differences in metabolic response to intraperitoneally injected tyramine were examined in young (3-4 month) and old (20-24 month) Sprague-Dawley and Fischer 344 rats. Fischer 344 rats were found to be significantly more sensitive to tyramine than Sprague—Dawley. Optimal doses were 2 mg/kg body weight for young F344, 20 mg/kg for young Sprague—Dawley, 5 mg/kg for old F344, and <40 mg/kg for old Sprague—Dawley. Significantly higher doses were required by old rats than young. Mechanisms of these age-and strain-related differences in response are discussed. This information could well be important in selecting appropriate ages and strains of animals for experimental use, especially in aging research.

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