Comparison of the Protein Profile of Established and Regressed Hypertension-Induced Left Ventricular Hypertrophy
- 30 December 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 5 (2) , 404-413
- https://doi.org/10.1021/pr0503275
Abstract
Established left ventricular hypertrophy (LVH) showed a significant alteration in the cardiac protein profile compared with normal heart. The main finding of this work was to identify proteins differently expressed in hypertension-induced LVH and the fact that after regression of LVH (histologically determined), the proteome still maintains a number of expressed proteins characteristic of the hypertrophied heart. These unrecovered proteins play an essential role in the energy production pathway, in cellular stress defense and also in hypertrophy regulation. Keywords: cardiac hypertrophy • hypertension • proteomics • antihypertensive drugsKeywords
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