Gene Affecting Superoxide Dismutase Activity Linked to the Histocompatibility Complex in H-2 Congenic Mice
- 4 January 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4426) , 86-87
- https://doi.org/10.1126/science.7350646
Abstract
The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.Keywords
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