Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent
- 1 September 2004
- journal article
- research article
- Published by Optica Publishing Group in Optics Letters
- Vol. 29 (17) , 2016-2018
- https://doi.org/10.1364/ol.29.002016
Abstract
We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent’s spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.Keywords
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