Tetrazolylacetic acids

Abstract
The syntheses of several 1-,2- and 5-tetrazolylacetic acids are described. Isomeric tetrazolylacetic esters can be separated by fractional distillation or crystallization. 5-Hydroxytetrazole reacts with ethyl bromoacetate in the presence of triethylamine to give 1,4-dicarbethoxymethyl-5-tetrazolone. The use of nuclear magnetic resonance spectroscopy for the assignment of structural isomers is discussed.

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