Effects of buprenorphine on motor activity of the sphincter of Oddi in man
- 1 February 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 36 (2) , 203-204
- https://doi.org/10.1007/bf00609196
Abstract
Buprenorphine, (Temgesic), a N-cyclopropylmethyl derivative of oripavine, is both an agonist and antagonist of morphine. Its effect on the motility of the sphinceter of Oddi (SO) in humans have been investigated by endoscopic manometry (EM). Buprenorphine leads to a significant decrease in the amplitude of SO contraction waves without altering other parameters. Thus, it has no morphine-like effect on SO motility, but it does act like a partial antagonist of morphine in reducing the amplitude of SO contraction waves.This publication has 9 references indexed in Scilit:
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