PROMINENT PERIPHERAL EDEMA ASSOCIATED WITH PRIMARY ALDOSTERONISM DUE TO AN ADRENOCORTICAL ADENOMA

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Abstract
A case of primary aldosteronism in association with prominent peripheral edema is described. There were no abnormalities of plasma protein or of cardiac or renal function which could account for the edema formation; aldosteronism was the only demonstrable etiologic factor. Removal of an adrenocortical adenoma cured the edema and the features of primary aldosteronism immediately. The edema reappeared postoperatively when desoxycorticosterone was administered and promptly disappeared when it was stopped. Extensive preoperative and postoperative metabolic studies are presented and discussed in detail. The findings suggest a reciprocal relationship between hypokaliemic alkalosis and edema as manifestations of aldosteronism.