An Aromatase-Producing Sex-Cord Tumor Resulting in Prepubertal Gynecomastia

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Abstract
GYNECOMASTIA in prepubertal children usually results from an increase in endogenous estrogen production. Estrogen biosynthesis involves the transformation of steroid precursors to androgens and then conversion of androgens to estrogens by the enzyme aromatase. Excessive production of estrogen may result from an increase in levels of endogenous substrate, aromatase activity, or both.