Nortriptyline E‐10‐Hydroxylation in Vitro Is Mediated by Human CYP2D6 (High Affinity) and CYP3A4 (Low Affinity): Implications for Interactions with Enzyme‐Inducing Drugs
- 1 June 1999
- journal article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 39 (6) , 567-577
- https://doi.org/10.1177/00912709922008173
Abstract
The human cytochrome P450 (CYP) isoforms mediating nortriptyline 10‐hydroxylation have been identified using kinetic studies on heterologously expressed human CYPs and chemical inhibition studies on ...Keywords
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