WR‐1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells

This publication has 23 references indexed in Scilit:

• Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against fast neutroninduced strand breakage
  International Journal of Radiation Biology, 1997
• Polyamine involvement in the cell cycle, apoptosis, and autoimmunity
  Medical Hypotheses, 1995
• Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action
  Carcinogenesis: Integrative Cancer Research, 1995
• Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278
  Carcinogenesis: Integrative Cancer Research, 1995
• Altered Phosphorylation, Biosynthesis and Degradation of the 170 kDa Isoform of Topoisomerase II in Amsacrine-Resistant Human Leukemia Cells
  Biochemical and Biophysical Research Communications, 1993
• Topological complexes between DNA and topoisomerase II and the effects of polyamines
  Biochemistry, 1989
• Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells
  Nature, 1986
• DNA topoisomerase activities in concanavalin A‐stimulated lymphocytes
  FEBS Letters, 1984
• Purification and characterization of the DNA untwisting enzyme from rat liver
  Biochemistry, 1976
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
  Analytical Biochemistry, 1976