Influence of Therapy with Recombinant Erythropoietin on Serum Levels of Neopterin in Hemodialyzed Subjects
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in American Journal of Nephrology
- Vol. 11 (4) , 281-283
- https://doi.org/10.1159/000168322
Abstract
The authors wished to investigate some aspects of the cell-mediated immunity in hemodialyzed subjects undergoing a treatment with recombinant erythropoietin (rHuEPO). The study was carried out through the dosage of the serum levels of neopterin, a substance produced by the macrophages and usable as a marker of their state of activation. The results show a significant reduction of the serum levels of pteridine already at the second month of treatment with rHuEPO (61 ± 9 vs. 95 ± 12 nmol/l), thus proving a probable inhibitory action carried out by erythropoietin on certain cells of the immune system.Keywords
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