A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder
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Open Access
- 1 May 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 57 (5) , 481-489
- https://doi.org/10.1001/archpsyc.57.5.481
Abstract
ALTHOUGH MOST treatment studies of bipolar disorder have focused on acute episodes, the maintenance phase of treatment dominates clinical treatment. Maintenance studies conducted a quarter of a century ago concluded that lithium was effective in preventing both manic and depressive episodes of bipolar disorder,1-5 but more recent open-label studies of lithium have reported less favorable treatment outcomes.6-10Keywords
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