Effect of L-Glutaminase on Transformation and DNA Synthesis of Normal Lymphocytes
- 1 January 1972
- journal article
- Published by S. Karger AG in Acta Haematologica
- Vol. 48 (1) , 12-15
- https://doi.org/10.1159/000208432
Abstract
The transformation of lymphocytes by phytohemagglutinin and the uptake of thymidine by DNA are completely inhibited by 17 mlU/ml L-glu taminase GA:1.2. The transformation is also inhibited by 1,700 mlU EC2 L-asparaginase/ml, which is estimated to have 34 mlU/ml of L-glutaminase activity.Therefore, glutamine deficiency may be responsible for the inhibition of transformation both by L-glutaminase GA:1.2 and by EC2 L-asparaginase.Keywords
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