A STUDY OF A FAMILY OF GOITROUS CRETINS*†

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Abstract
Observations were made on 3 cretinous siblings and 1 normal sibling. These patients had large goiters. Radioactive iodine accumulated rapidly in these goiters and remained there in high concn. After a dose of K thiocyanate there was a rapid decline in the radioactivity registered over the glands. The accumulation of radioactive iodine in the normal sibling proceeded at a normal rate and was not affected by K thiocyanate. Therefore, the goitrous siblings accumulated radioactive iodine, but were unable to incorporate it into a protein complex.