Atrophy of the Corpus Callosum, Cortical Hypometabolism, and Cognitive Impairment in Corticobasal Degeneration

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Abstract
CORTICOBASAL degeneration (CBD) is a neurodegenerative disorder with a distinctive asymmetrical akinetic-rigid syndrome in which cerebral cortical signs are the characteristic features.1,2 The clinical presentation of cortical dysfunction ranges from the localized cortical signs, including apraxia, cortical sensory loss, alien hand signs, and cortical reflex myoclonus, to generalized cognitive disturbance.3,4 Although these cortical signs may be the result of the involvement of specific regions that are important for higher cerebral functions, the mechanisms of cerebral cortical dysfunction in this disease are not completely clarified.