EFFECTS OF TESTOSTERONE PROPIONATE AND ENVIRONMENTAL TEMPERATURE ON NITROGEN BALANCE AND WOUND HEALING OF RATS WITH AND WITHOUT FEMORAL FRACTURE

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Abstract
Testosterone exerted a sparing effect on nitrogen urinary excretion and balance in pair-fed rats with femoral fracture, dorsal skin incision, and subcutaneously implanted polyvinyl alcohol sponges, whether kept at 22 or 30 degrees C for 1 week postoperatively. No difference in 14-or 21-day wounds was observed among rats with dorsal skin incision and sponge implants, kept at 22 degrees, and starting immediately after operation, given daily IM injections of either 3 mg or 1 mg testosterone propionate in peanut oil, compared with similarly wounded rats given saline or peanut oil injections. Wound healing was impaired in rats kept at 22 degrees for 7 days following a skin incision, sponge implants, and femoral fracture. Testosterone administration begun immediately after operation, 2 mg/day subcutaneously, did not improve the impaired healing of pair-fed rats with fracture compared with rats without fracture. There was somewhat less collagen and a higher ratio of ground substance to collagen in the skin incisions and sponge granulomas of the testosterone group. No differences in wound healing were observed in pair-fed rats moved to a 30 degrees room postoperatively, among rats with or without fracture, nor among rats with femoral fracture given testosterone or saline subcutaneously.

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