ENHANCEMENT OF CARDIAC PHOSPHORYLASE ACTIVATING EFFECT OF DIBUTYRYL CYCLIC-AMP BY THYROID-HORMONE
- 1 January 1977
- journal article
- research article
- Vol. 16 (4) , 735-743
Abstract
The injection of dibutyryl cyclic[c]AMP into the perfused rat heart resulted in dose-dependent increases in contractile force and phosphorylase a activity. In hearts from hyperthyroid animals both responses were markedly enhanced. The hyperthyroid state may produce changes in the heart making it more responsive to cAMP. Such a change could occur at the level of protein kinase. In hyperthyroidism, the heart may be more capable of taking up dibutyryl cAMP or of converting it to an active product.This publication has 7 references indexed in Scilit:
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