In vivo and In vitro Conversion of Folic Acid to Citrovorum Factor by Rat.
- 1 December 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 87 (3) , 498-500
- https://doi.org/10.3181/00379727-87-21423
Abstract
Rat liver contains an enzyme system which converts pteroylglutamic acid (PGA) to citrovorum factor (CF). Dietary homocysteine and cysteine enhance the urinary excretion of CF by rats receiving PGA, the former more so than the latter. In vitro conversion of PGA to CF by rat liver homogenate is enhanced by homocysteine, serine and formate. The stimulatory effect of homocysteine on CF synthesis is enhanced by added serine, but inhibited by added formate.Keywords
This publication has 4 references indexed in Scilit:
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- THE EFFECT OF ASCORBIC ACID ON THE URINARY EXCRETION OF CITROVORUM FACTOR DERIVED FROM FOLIC ACID1951
- Synthesis of Citrovorum Factor From Folic Acid By Liver Slices; Augmentation By Ascorbic Acid.Experimental Biology and Medicine, 1950
- THE EFFECT OF FOLIC ACID UPON THE URINARY EXCRETION OF THE GROWTH FACTOR REQUIRED BY LEUCONOSTOC CITROVORUMJournal of Biological Chemistry, 1949