Long-term effects of pergolide in the treatment of restless legs syndrome
- 22 May 2001
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 56 (10) , 1399-1402
- https://doi.org/10.1212/wnl.56.10.1399
Abstract
An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.Keywords
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