Rational design of an animal model for alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent
Open Access
- 30 April 1996
- journal article
- Published by Elsevier in Neurobiology of Aging
- Vol. 17 (2) , 173-182
- https://doi.org/10.1016/0197-4580(95)02076-4
Abstract
No abstract availableKeywords
This publication has 43 references indexed in Scilit:
- β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityCell, 1995
- Rapid induction of Alzheimer A beta amyloid formation by zincScience, 1994
- Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.Journal of Clinical Investigation, 1994
- Expression of APP in Brains of Transgenic Mice Containing the Entire Human APP GeneBiochemical and Biophysical Research Communications, 1993
- Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic miceNature Genetics, 1993
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosomeNature Genetics, 1993
- Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein EScience, 1992
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's DiseaseNew England Journal of Medicine, 1989