Glycoprotein I of Varicella-Zoster Virus Is Required for Viral Replication in Skin and T Cells
Open Access
- 15 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (16) , 8468-8471
- https://doi.org/10.1128/jvi.76.16.8468-8471.2002
Abstract
Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.Keywords
This publication has 28 references indexed in Scilit:
- The Requirement of Varicella Zoster Virus Glycoprotein E (gE) for Viral Replication and Effects of Glycoprotein I on gE in Melanoma CellsVirology, 2002
- Essential Role Played by the C-Terminal Domain of Glycoprotein I in Envelopment of Varicella-Zoster Virus in the trans -Golgi Network: Interactions of Glycoproteins with TegumentJournal of Virology, 2001
- Viral proteinsPublished by Cambridge University Press (CUP) ,2000
- Varicella-Zoster Virus gE Escape Mutant VZV-MSP Exhibits an Accelerated Cell-to-Cell Spread Phenotype in both Infected Cell Cultures and SCID-hu MiceVirology, 2000
- Trafficking of Varicella-Zoster Virus Glycoprotein gI: T 338 -Dependent Retention in the trans -Golgi Network, Secretion, and Mannose 6-Phosphate-Inhibitable Uptake of the EctodomainJournal of Virology, 2000
- The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouseProceedings of the National Academy of Sciences, 1998
- Intracellular Transport of the Glycoproteins gE and gI of the Varicella-Zoster VirusJournal of Biological Chemistry, 1998
- Complex formation facilitates endocytosis of the varicella-zoster virus gE:gI Fc receptor.1998
- GLYCOPROTEINS ENCODED BY VARICELLA-ZOSTER VIRUS: Biosynthesis, Phosphorylation, and Intracellular TraffickingAnnual Review of Microbiology, 1990
- The Complete DNA Sequence of Varicella-Zoster VirusJournal of General Virology, 1986